Dual-prodrug
Web10 dic 2024 · Herein, we developed a dual-activated prodrug, BTC, that contains three functional components: a glutathione (GSH)-responsive BODIPY-based photosensitizer with a photoinduced electron transfer (PET) effect between BODIPY and the 2,4-dinitrobenzenesulfonate (DNBS) group, and an ROS-responsive thioketal linker … WebSmart activatable and traceable dual-prodrug for image-guided combination photodynamic and chemo-therapy. Activatable photosensitizers (PSs) and chemo-prodrugs are highly …
Dual-prodrug
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Web3 giu 2024 · Medical Definition of Prodrug. Prodrug: A precursor (forerunner) of a drug. A prodrug must undergo chemical conversion by metabolic processes before becoming an … Web31 lug 2024 · BCPN is purely constructed from a tumor acidity and reduction dual-responsive oxaliplatin (OXA) prodrug for triggering immunogenic cell death (ICD) and eliciting antitumor immunity, and a reduction-activatable homodimer of NLG919 for inactivating indoleamine 2,3-dioxygenase 1, which is a key regulator for ITM.
Web3 giu 2024 · Prodrug: A precursor (forerunner) of a drug. A prodrug must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent. … WebAs FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To ameliorate their respective …
Web23 mag 2024 · A dual mitochondria- and DNA-targeting coumarin-Pt(IV) prodrug has been developed, which dramatically enhances the anticancer performance and has reduced side-effects compared to cisplatin. … Web9 mag 2024 · Abstract. As FDA-approved chemotherapeutic agents, cisplatin, oxaliplatin, and 5-fluorouracil are widely used in clinic but limited by severe side-effects. To …
Web1 feb 2024 · The present study illustrated the first example of nanomedicine with a dual prodrug motif, precisely and concomitantly activated by the same subcellular stimuli …
Web6 mar 2024 · Dual stimulus-triggered bioorthogonal nanosystem for spatiotemporally controlled prodrug activation and near-infrared fluorescence imaging - Chemical … alberto termiteWeb23 mar 2024 · This dual-targeting strategy aims to lead the effective oncolysis by using a combination of the folate receptor-targeted nanoreactor loaded with GOX and the COX-2 … alberto terrazas seyffertWeb10 feb 2024 · Eventually, systemic administration of the dual prodrug construct exerted potent tumor suppression efficacy in treatment of intractable solid breast adenocarcinoma, as well as an appreciable safety profile. The present study illustrated the first example of nanomedicine with a dual prodrug motif, ... alberto terrazas sozaWebCovalently functionalized halloysite nanotubes (HNTs) were successfully employed as dual-responsive nanocarriers for curcumin (Cur). Particularly, we synthesized HNT-Cur prodrug with a controlled curcumin release on dependence of both intracellular glutathione (GSH) and pH conditions. alberto terassoWebProdrug definition, an inactive substance that is converted to a drug within the body by the action of enzymes or other chemicals. See more. alberto terraniWebThe combination therapy of cisplatin (CDDP) and metformin (MET) is a clinical strategy to enhance therapeutic outcomes in lung cancer. However, the efficacy of this … alberto terranovaWebDesign of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy Jiajiang Xie,1,2,* Zhongxiong Fan,2,* Yang Li,2,* Yinying Zhang,2 Fei Yu,3 Guanghao Su,4 Liya Xie,5 Zhenqing Hou2 1Xiamen Xianyue Hospital, Xiamen, China; 2Research Center of Biomedical Engineering of … alberto terziari